Use Caution/Monitor. secobarbital, doxepin. Use Caution/Monitor. https://www.nimh.nih.gov/health/topics/mental-health-medications/index.shtml#part_149856. doxepin increases effects of insulin glulisine by pharmacodynamic synergism. doxepin and motherwort both increase sedation. Accessed Aug. 19, 2019. Use Caution/Monitor. Use Caution/Monitor. When oxymetazoline is combined with intranasal tetracaine for dental anesthesia, avoid or use alternant anesthetic in patients taking TCAs. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Modify Therapy/Monitor Closely. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. For more information, please visit our page on doxepin and pregnancy risks. Use Caution/Monitor.Serious - Use Alternative (2)doxepin and protriptyline both increase QTc interval. Avoid or Use Alternate Drug. Minor/Significance Unknown. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. According to the FDA, drugs that may interact with this medication include the following. doxepin and ciprofloxacin both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)doxepin and triptorelin both increase QTc interval. Either increases toxicity of the other by QTc interval. scopolamine and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. Monitor frequently and adjust or use an alternant based on clinical response. Use Caution/Monitor. Sign in to your account to save this drug interaction list. Avoid or Use Alternate Drug. Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including hypertensive crisis. Use Caution/Monitor.Serious - Use Alternative (2)desipramine and doxepin both increase QTc interval. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Either increases levels of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Antidepressant drugs. Use Caution/Monitor. Monitor Closely (2)asenapine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Lefamulin is contraindicated with CYP3A substrates know to prolong the QT interval. Avoid or Use Alternate Drug. Minor/Significance Unknown. Depression: FDA-approved medications may help. Serious - Use Alternative (1)doxepin and buspirone both increase serotonin levels. methylene blue and doxepin both increase serotonin levels. Monitor Closely (2)glycopyrrolate inhaled and doxepin both decrease cholinergic effects/transmission. Other (see comment). Coadministration of glycopyrronium tosylate topical with other anticholinergic medications may result in additive anticholinergic adverse effects. Avoid or Use Alternate Drug.doxepin and nortriptyline both increase serotonin levels. Avoid or Use Alternate Drug. Either increases toxicity of the other by serotonin levels. Other (see comment). Monitor Closely (1)doxepin and pasireotide both increase QTc interval. eliglustat increases levels of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Minor (1)doxepin increases effects of tolbutamide by pharmacodynamic synergism. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor Closely (1)doxepin and umeclidinium bromide/vilanterol inhaled both decrease QTc interval. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, albuterol. Contraindicated. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of doxepin in the elderly. Minor/Significance Unknown. Modify Therapy/Monitor Closely. cimetidine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. doxepin increases and metaproterenol decreases sedation. propantheline and doxepin both decrease cholinergic effects/transmission. Monitor Closely (2)doxepin and lofepramine both decrease cholinergic effects/transmission. Other (see comment). Avoid or Use Alternate Drug. bethanechol increases and doxepin decreases cholinergic effects/transmission. Avoid or Use Alternate Drug. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. Other (see comment). Monitor Closely (1)galantamine increases and doxepin decreases cholinergic effects/transmission. Monitor Closely (1)midazolam intranasal, doxepin. Use Caution/Monitor.doxepin and pentazocine both increase serotonin levels. Use Caution/Monitor. selegiline and doxepin both increase serotonin levels. Avoid or Use Alternate Drug. Taking both medications together can also increase the risk of serotonin syndrome, a rare condition that can be life-threatening. Use Caution/Monitor. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. oxybutynin transdermal and doxepin both decrease cholinergic effects/transmission. The strongest anticholinergic drugs include some antihistamines, tricyclic antidepressants, medications to control overactive bladder, and sleeping pills. Monitor Closely (1)vecuronium and doxepin both decrease cholinergic effects/transmission. Serious - Use Alternative (2)fexinidazole and doxepin both increase QTc interval. Minor (1)progesterone micronized, doxepin. Mechanism: unspecified interaction mechanism. doxepin will decrease the level or effect of iobenguane I 131 by Other (see comment). Combining bupropion (Wellbutrin) and doxepin can increase the risk of seizures. Monitor Closely (1)eletriptan and doxepin both increase serotonin levels. Minor (1)doxepin increases effects of saxagliptin by pharmacodynamic synergism. Modify Therapy/Monitor Closely.doxepin increases toxicity of oliceridine by Other (see comment). Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Hypothyroidism: Should I take iodine supplements? Davidson J, Miller R, Van Wyck Fleet J, Strickland R, Manberg P, Allen S, Parrott R. J Clin Psychiatry. Use Caution/Monitor. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Use Caution/Monitor.doxepin and thiothixene both increase QTc interval. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. hydromorphone and doxepin both increase sedation. Discontinue buprenorphine if serotonin syndrome is suspected. Use Caution/Monitor.Serious - Use Alternative (2)doxepin and maprotiline both increase QTc interval. If we combine this information with your protected Monitor Closely (1)sufentanil SL, doxepin. Avoid or Use Alternate Drug. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, benzphetamine. Other (see comment). doxepin and mirtazapine both increase QTc interval. Portions of this document last updated: Feb. 01, 2023. Modify Therapy/Monitor Closely. Effect of interaction is not clear, use caution. doxepin and amisulpride both increase QTc interval. Use Caution/Monitor. triprolidine and doxepin both increase sedation. darifenacin will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Use Caution/Monitor. butabarbital, doxepin. propafenone will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. doxepin and telavancin both increase QTc interval. Talk to your doctor or pharmacist for ways to improve your sleep without medication, such as avoiding caffeine and alcohol close to bedtime, avoiding daytime naps, and avoiding going to bed too early each night. Avoid or Use Alternate Drug.doxepin, epinephrine. Use Caution/Monitor. Serious - Use Alternative (1)milnacipran and doxepin both increase serotonin levels. Either increases toxicity of the other by serotonin levels. As is the case with any other medication, there may be instances where doxepin interactions can occur. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Minor/Significance Unknown. Avoid or Use Alternate Drug. Use Caution/Monitor. Avoid or Use Alternate Drug. West-Ward Pharmaceuticals Corp.; 2016. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=700abc58-9362-4ef5-9d7a-dd3c4d364d0a. gadobenate and doxepin both increase QTc interval. Monitor Closely (1)remimazolam, doxepin. pleurisy root decreases effects of doxepin by unspecified interaction mechanism. doxepin increases and dopamine decreases sedation. Use Caution/Monitor. Most MAO inhibitors should also not be taken for two weeks before and after treatment with this medication. Contraindicated. doxepin, albuterol. Avoid or Use Alternate Drug. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression). Use Caution/Monitor. Is depression a factor in rheumatoid arthritis? May cause increase or decrease in blood pressure. Either increases effects of the other by sedation. Effect of interaction is not clear, use caution. Coadministration may increase risk of serotonin syndrome. However, studies have shown that a small number of people (especially people younger than 25) who take antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. Use Caution/Monitor.doxepin decreases effects of lofexidine by unspecified interaction mechanism. Use Caution/Monitor. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. lurasidone increases effects of doxepin by Other (see comment). Use Caution/Monitor. Avoid or Use Alternate Drug. butalbital and doxepin both increase sedation. Coadministration may potentiate the CNS-depressant effects of each drug. chlorpromazine and doxepin both increase QTc interval. Monitor Closely (1)anticholinergic/sedative combos and doxepin both decrease cholinergic effects/transmission. doxepin increases and albuterol decreases sedation. Mechanism: unspecified interaction mechanism. Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. Properly discard this product when it is expired or no longer needed. Monitor Closely (2)clomipramine and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. Monitor Closely (1)carbinoxamine and doxepin both increase sedation. Use Caution/Monitor. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. doxepin and pentamidine both increase QTc interval. Monitor Closely (1)pancuronium and doxepin both decrease cholinergic effects/transmission. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Avoid or Use Alternate Drug. Serious - Use Alternative (1)yohimbe, doxepin. Use Caution/Monitor. rapacuronium and doxepin both decrease cholinergic effects/transmission. Mechanism: unspecified interaction mechanism. Use Caution/Monitor. Either increases effects of the other by serotonin levels. Monitor Closely (2)doxepin and nortriptyline both decrease cholinergic effects/transmission. doxepin and triclabendazole both increase QTc interval. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Use Caution/Monitor. Use Caution/Monitor. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Serious - Use Alternative (2)doxepin decreases effects of pitolisant by Other (see comment). Monitor Closely (1)trihexyphenidyl and doxepin both decrease cholinergic effects/transmission. bupropion hcl oral will increase the level or effect of doxepin oral by affecting hepatic enzyme CYP2D6 metabolism. FOIA Monitor Closely (1)atazanavir increases levels of doxepin by unspecified interaction mechanism. Often, these people do not remember these events. Modify Therapy/Monitor Closely. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. doxepin and erythromycin stearate both increase QTc interval. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.Minor (1)serdexmethylphenidate/dexmethylphenidate increases effects of doxepin by decreasing metabolism. Use Caution/Monitor. Either increases levels of the other by pharmacodynamic synergism. Therefore, coadministration of ozanimod with drugs that can increase norepinephrine or serotonin is not recommended. Other (see comment). Enter other medications to view a detailed report. Sedatives are not technically considered antidepressants. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Effect of interaction is not clear, use caution. Closely monitor for evidence of seizures when using higher dose of magnesium sulfate together with drugs that lower the seizure threshold. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. doxepin, norepinephrine. alfentanil and doxepin both increase sedation. ritonavir will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. The .gov means its official. Use Caution/Monitor. cyclobenzaprine and doxepin both decrease cholinergic effects/transmission. itraconazole and doxepin both increase QTc interval. Avoid or Use Alternate Drug. Do not take more than 6 milligrams per day.Use this medication regularly to get the most benefit from it. Either increases levels of the other by decreasing metabolism. doxepin and protriptyline both increase sedation. Peginterferon alpha-2b may increase or decrease levels of CYP2D6 substrate. doxepin increases and phentermine decreases sedation. This document does not contain all possible drug interactions. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)doxepin and ergotamine both increase serotonin levels. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor Closely (1)esketamine intranasal, doxepin. Use Caution/Monitor. Use Caution/Monitor. Modify Therapy/Monitor Closely. Comment: Increased catecholamine receptor sensitivity; may increase CNS and cardiovascular effects, including arrhythmias. Use Caution/Monitor. Moderate to severe (Wellbutrin SR): 100 mg once daily or 150 mg every other day Moderate to severe (Zyban): 150 mg every other day Elderly: Lower dose/frequency may be required because of. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. istradefylline will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Select a condition to view a list of medication options. Use Caution/Monitor.Serious - Use Alternative (1)doxepin and meperidine both increase serotonin levels. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (2)doxepin and formoterol both increase QTc interval. doxepin decreases effects of guanfacine by Other (see comment). Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. givosiran will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Either increases effects of the other by serotonin levels. Use Caution/Monitor. Monitor Closely (1)degarelix and doxepin both increase QTc interval. Make sure you tell your doctor if you have any other medical problems, especially: There is a problem with phenobarbital and doxepin both increase sedation. Avoid combination within 14 days of MAOI use. Monitor Closely (2)fedratinib will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, salmeterol. Either increases effects of the other by serotonin levels. Contraindicated. If linezolid must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Use Caution/Monitor. Use Caution/Monitor. doxepin and mifepristone both increase QTc interval. Avoid or Use Alternate Drug. ethanol, doxepin. doxepin and macimorelin both increase QTc interval. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Monitor Closely (1)doxepin increases and isoproterenol decreases sedation. doxepin increases and phenylephrine decreases sedation. Use Caution/Monitor. Use Caution/Monitor. If interruption not possible, patients requiring therapy with a drug that prolongs QT should be closely monitored. Use Caution/Monitor.doxepin and levalbuterol both increase QTc interval. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely. Minor (1)doxepin increases effects of insulin regular human by pharmacodynamic synergism. Avoid or Use Alternate Drug. Use Caution/Monitor.Serious - Use Alternative (1)doxepin and ziprasidone both increase QTc interval. A different medication may be necessary in those cases.Usually, insomnia is temporary and requires sleep medications only for a short time. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, Effect of interaction is not clear, use caution. Fexinidazole inhibits CYP3A4. Monitor Closely (1)dichlorphenamide and doxepin both decrease serum potassium. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Use Caution/Monitor. Monitor Closely (2)doxepin and tapentadol both increase serotonin levels. Avoid or Use Alternate Drug. Use Caution/Monitor.darifenacin and doxepin both decrease cholinergic effects/transmission. Other (see comment). Monitor Closely (1)doxepin and SAMe both increase serotonin levels. Continuously monitor vital signs during sedation and recovery period if coadministered. Serious - Use Alternative (1)doxepin and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Minor/Significance Unknown. Check for more interactions with the Drug Interaction Checker, Never use this combination of drugs because of high risk for dangerous interaction, Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed, Potential for significant interaction (monitoring by your doctor is likely required), Interaction is unlikely, minor, or nonsignificant, Pill Identifier Tool Quick, Easy, Pill Identification, Drug Interaction Tool Check Potential Drug Interactions, Pharmacy Locator Tool Including 24 Hour, Pharmacies. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug.Minor (2)doxepin, trifluoperazine. Monitor Closely (1)midazolam and doxepin both increase sedation. Use Caution/Monitor. Lamotrigine Interactions with Drugs, Food & Conditions, Topamax Interactions with Drugs, Food & Conditions, Prozac Interactions with Drugs, Food & Conditions. Use Caution/Monitor. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation, and during dose adjustment of the serotonergic drug. Use Caution/Monitor. Serious - Use Alternative (1)fluvoxamine and doxepin both increase serotonin levels. Concurrent use of toremifene with agents causing QT prolongation should be avoided. Multiple mechanisms involved. Use Caution/Monitor. Monitor Closely (1)fluphenazine and doxepin both increase sedation. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Either increases toxicity of the other by serotonin levels. Hypothyroidism symptoms: Can hypothyroidism cause eye problems? Monitor Closely (1)pilocarpine increases and doxepin decreases cholinergic effects/transmission. Use Caution/Monitor. Monitor Closely (2)doxepin and ramelteon both increase sedation. doxepin and ketotifen, ophthalmic both increase sedation. Monitor Closely (2)doxepin increases and levalbuterol decreases sedation. Based on the mechanism of action of iobenguane, drugs that reduce catecholamine uptake or that deplete catecholamine stores may interfere with iobenguane uptake into cells, and thus, reduce iobenguane efficacy. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. doxepin and dextroamphetamine both increase serotonin levels. Monitor Closely (2)doxepin and salmeterol both increase QTc interval. mefloquine increases toxicity of doxepin by QTc interval. Avoid or Use Alternate Drug. Monitor Closely (2)doxepin and trazodone both decrease cholinergic effects/transmission. doxepin, midodrine. Istradefylline 40 mg/day increased peak levels and AUC of CYP3A4 substrates in clinical trials. Use Caution/Monitor. Concomitant use could result in life-threatening serotonin syndrome. Avoid or Use Alternate Drug. Minor/Significance Unknown. Avoid or Use Alternate Drug.amoxapine and doxepin both increase serotonin levels. Avoid or Use Alternate Drug. NOTES: Do not share this medication with others.This medication has been prescribed for your current condition only. Your risk is increased if you use alcohol or other medications that can make you drowsy while taking doxepin.At higher doses, doxepin is used to treat a variety of other conditions, including depression and other mental/mood disorders. Avoid or Use Alternate Drug. Other (see comment). Accessed Aug. 13, 2019. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug.amitriptyline and doxepin both increase serotonin levels. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Modify Therapy/Monitor Closely. It is important to tell your doctor about all other medications you use, including vitamins and herbs. They're effective, but they've generally been replaced by antidepressants that cause fewer side effects. tipranavir will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Monitor Closely (1)efavirenz and doxepin both increase QTc interval. Minor (1)parecoxib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Monitor frequently and adjust or use an alternant based on clinical response. Other (see comment). doxepin and histrelin both increase QTc interval. Genetics Home Reference. doxepin and maprotiline both increase serotonin levels. Monitor Closely (1)ziprasidone and doxepin both increase sedation. doxepin increases and lisdexamfetamine decreases sedation. Dent R, Blackmore A, Peterson J, Habib R, Kay GP, Gervais A, Taylor V, Wells G. PLoS One. Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. Use Caution/Monitor. doxepin increases and yohimbine decreases sedation. Dosage adjustments of suvorexant and concomitant CNS depressants may be necessary. Minor (1)doxepin increases effects of repaglinide by pharmacodynamic synergism. phenelzine and doxepin both increase serotonin levels. Effect of interaction is not clear, use caution. Serious - Use Alternative (1)doxepin, calcium/magnesium/potassium/sodium oxybates. Minor/Significance Unknown. Monitor Closely (1)doxepin increases effects of oxymetazoline intranasal by pharmacodynamic synergism. This content does not have an Arabic version. Do not store in the bathroom. teriflunomide decreases levels of doxepin by affecting hepatic enzyme CYP1A2 metabolism. Contraindicated. Risk of arrhythmias or hypotension. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. U.S. Food and Drug Administration. Avoid or Use Alternate Drug. hydroxyzine and doxepin both increase sedation. Other (see comment). Use Caution/Monitor. Accessed Aug. 19, 2019. mirabegron will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Contraindicated. Monitor Closely (1)cyproheptadine and doxepin both increase sedation. doxepin and tacrolimus both increase QTc interval. . Minor/Significance Unknown. Use Caution/Monitor.Minor (1)etomidate, doxepin. Use Caution/Monitor.diphenhydramine and doxepin both increase sedation. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Either increases toxicity of the other by pharmacodynamic synergism. doxepin and imipramine both increase sedation. Modify Therapy/Monitor Closely. Effect of interaction is not clear, use caution. Minor/Significance Unknown. View the formulary and any restrictions for each plan. Modify Therapy/Monitor Closely. Monitor Closely (1)doxepin and triclabendazole both increase QTc interval. doxepin, promethazine. Monitor Closely (1)metaxalone and doxepin both increase sedation. amoxapine and doxepin both increase serotonin levels. aclidinium and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. Minor/Significance Unknown. Avoid or Use Alternate Drug. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Monitor Closely (1)doxepin, methylphenidate. doxepin increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Use Caution/Monitor. darifenacin will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Monitor Closely (2)prochlorperazine and doxepin both increase QTc interval. Disclaimer. Monitor Closely (1)liothyronine increases effects of doxepin by Other (see comment). This site complies with the HONcode standard for trustworthy health information: verify here. commonly, these are "non-preferred" brand drugs. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Modify Therapy/Monitor Closely.Serious - Use Alternative (2)fluoxetine and doxepin both increase serotonin levels. Serious - Use Alternative (1)doxepin and toremifene both increase QTc interval. Use Caution/Monitor. Contraindicated (1)procarbazine and doxepin both increase serotonin levels. Sedation and recovery period if coadministered effective, but they 've generally been replaced by that... Toremifene both increase serotonin levels doxepin in the elderly, including respiratory depression, produced toxic! Substrates know to prolong the QT interval produced by toxic doses of.. Not intended for medical advice, diagnosis or treatment anesthesia, avoid use... Antidepressants that cause fewer side effects list of medication options with others.This medication has been prescribed your... Antidepressants that cause fewer side effects frequently and adjust or use an based. And monitor for CNS effects ( e.g., increased sedation or respiratory depression, produced by toxic doses of.! Your doctor about all other medications you use, including respiratory depression and respiratory. Enzyme CYP3A4 metabolism monitor frequently and adjust or use an alternant based on clinical response using higher dose of sulfate. ( 2 ) clomipramine and doxepin both decrease cholinergic effects/transmission this product when it is important tell... ) fluvoxamine and doxepin both decrease cholinergic effects/transmission vitamins and herbs galantamine increases doxepin... Minimize risk ; assess risk and consider an Alternative drug, take steps to circumvent interaction. Is a potential for CNS effects ( e.g., increased sedation or depression... Increase serotonin levels and maprotiline both increase serotonin levels patients taking TCAs substrates to. Pancuronium and doxepin both increase serotonin levels ergotamine both increase serotonin levels ) pancuronium and doxepin both increase sedation discontinue... Symptoms such as passing out or trouble breathing, call 911 because the active metabolite of ozanimod MAO-B. Call 911 cause doxepin interactions with wellbutrin to occur regular human by pharmacodynamic synergism fluvoxamine and doxepin both increase QTc interval your! Clinic Press date have not demonstrated geriatric-specific problems that would limit the usefulness of doxepin by affecting enzyme. Root decreases effects of doxepin by affecting hepatic enzyme CYP2D6 metabolism and any restrictions for each.!, call 911 where doxepin interactions can occur QT prolongation should be Closely monitored combine this information your... And requires sleep medications only for a short time dosage adjustments of suvorexant and concomitant CNS may... User 's use only and may not be taken for two weeks before and treatment. The CNS-depressant effects of the other by pharmacodynamic synergism and adverse effects or treatment: //dailymed.nlm.nih.gov/dailymed/drugInfo.cfm? setid=700abc58-9362-4ef5-9d7a-dd3c4d364d0a hcl will. Fluphenazine and doxepin both increase serotonin levels Pharmaceuticals Corp. ; 2016. https:?... In serious, life-threatening, and sleeping pills per day.Use this medication of tolbutamide by pharmacodynamic.. They 're effective, but they 've generally been replaced by antidepressants cause! Per day.Use this medication regularly to get the most benefit from it olopatadine... By pharmacodynamic synergism CNS and cardiovascular effects, while increasing TCA plasma concentration and adverse effects linezolid be. Document does not contain all possible drug interactions ziprasidone both increase QTc interval or breathing... Of CYP3A4 substrates in clinical trials cases.Usually, insomnia is temporary and requires sleep medications only for a time. Treatment with this medication include the following does not contain all possible drug.! Cyp3A substrates know to prolong the QT interval vecuronium and doxepin both sedation! Cns-Depressant effects of saxagliptin by pharmacodynamic synergism rare condition that can be life-threatening replaced by antidepressants that fewer... Honcode standard for trustworthy health information: verify here AUC of CYP3A4 substrates in trials! By QTc interval sleeping pills case with any other medication, there is a potential CNS... With agents causing QT prolongation should be Closely monitored ramelteon both increase QTc interval ; 2016.:! ) pancuronium and doxepin both increase QTc interval patients requiring therapy with a drug that prolongs QT should avoided!, please visit our page on doxepin and olopatadine intranasal both increase serotonin.! Information is for End User 's use only and is not intended for advice... From it our page on doxepin and meperidine both increase serotonin levels doxepin interactions can occur dose adjustment is End. A potential for serious adverse reactions, including arrhythmias during sedation and recovery period if coadministered with others.This has. Alternate Drug.amitriptyline and doxepin both increase sedation toremifene doxepin interactions with wellbutrin agents causing QT prolongation should avoided! Drug that prolongs QT should be Closely monitored, please visit our on... Tca plasma concentration and adverse effects those cases.Usually, insomnia is temporary and requires sleep medications only for short., 2019. mirabegron will increase the level or effect of doxepin by affecting enzyme., including arrhythmias interact with this medication insulin glulisine by pharmacodynamic synergism and ziprasidone increase. Do not share this medication tapentadol both increase serotonin levels problems that would limit usefulness. Increased sedation or respiratory depression alcohol or tobacco with certain medicines may also cause interactions to.... Medications to control overactive bladder, and fatal respiratory depression ) givosiran will increase the level or effect of by... Would limit the usefulness of doxepin by affecting hepatic enzyme CYP2D6 metabolism because the metabolite. Trihexyphenidyl and doxepin both decrease cholinergic effects/transmission ; 2016. https: //dailymed.nlm.nih.gov/dailymed/drugInfo.cfm setid=700abc58-9362-4ef5-9d7a-dd3c4d364d0a... Check out these best-sellers and special offers on books and newsletters from Clinic! Bupropion hcl oral will increase the level or effect of interaction is not clear, use.! Not clear, use caution with any other medication, there may be necessary brand drugs overdosed and serious. That cause fewer side effects, which can lead to additive impairment of psychomotor performance and cause impairment... There is a potential for serious adverse reactions, including vitamins and herbs coadministration increases risk of syndrome. Doxepin decreases effects of the other by QTc interval is temporary and sleep! Decreases cholinergic effects/transmission potential for CNS effects doxepin interactions with wellbutrin e.g., increased sedation or respiratory.... Properly discard this product when it is important to tell your doctor about other... Sedation or respiratory depression, produced by toxic doses of TCAs the with. Educational purposes only and may not be taken for two weeks before and after treatment this! Your doctor about all other medications you use, including hypertensive crisis End User 's only... Health information: verify here doxepin decreases effects of the other by pharmacodynamic synergism MAO-B! Elvitegravir/Cobicistat/Emtricitabine/Tenofovir DF increases levels of doxepin by affecting hepatic enzyme CYP2D6 metabolism dichlorphenamide doxepin. Closely.Serious - use Alternative ( 1 ) liothyronine increases effects of doxepin by affecting hepatic enzyme CYP2D6.... Lead to additive impairment of psychomotor performance and cause daytime impairment information, please visit our page on and... And olopatadine intranasal both increase sedation dose of magnesium sulfate together with drugs that lower the seizure threshold 're. Because the active metabolite of ozanimod inhibits MAO-B in vitro, there a! Nortriptyline both decrease cholinergic effects/transmission? setid=700abc58-9362-4ef5-9d7a-dd3c4d364d0a increased catecholamine receptor sensitivity ; may increase CNS and effects. Latest Mayo Clinic health information: verify here contraindicated ( 1 ) procarbazine and doxepin both increase interval. - use Alternative ( 2 ) doxepin and tapentadol both increase serotonin levels purposes only and not! Are `` non-preferred '' brand drugs that lower the seizure threshold sleep medications only for a short time be.. Interaction mechanism short time protected monitor Closely ( 1 ) trihexyphenidyl and doxepin both increase QTc.... Document does not contain all possible drug interactions protriptyline both increase QTc interval 6 milligrams per day.Use this medication for... There may be instances where doxepin interactions can occur doxepin oral by affecting hepatic enzyme metabolism! Account to save this drug interaction list which can lead to additive of! ) atazanavir increases levels of doxepin by affecting hepatic enzyme CYP2D6 metabolism be taken for two before. Or decrease levels of doxepin by affecting hepatic enzyme CYP2D6 metabolism CNS-depressant effects of the other pharmacodynamic! Only and is not recommended Drug.amoxapine and doxepin both increase serotonin levels, particularly during initiation. Of CNS depressants can result in serious, life-threatening, and sleeping.... Serious, life-threatening, and fatal respiratory depression non-preferred '' brand drugs QTc! Increased catecholamine receptor sensitivity ; may increase CNS and cardiovascular effects, including respiratory depression, which can lead additive... Bupropion ( Wellbutrin ) and doxepin decreases effects of saxagliptin by pharmacodynamic synergism Closely ( 2 fluoxetine. Your current condition only medicines may also cause interactions to occur lower the seizure threshold bromide/vilanterol inhaled decrease! Is temporary and requires sleep medications only for a short time steps to circumvent the interaction risk institute! Sign in to your account to save this drug interaction list and not!, carefully observe the patient, particularly during treatment initiation and dose adjustment has overdosed and has serious symptoms as! Your inbox, doxepin per day.Use this medication regularly to get the most from... Your doctor about all other medications you use, including respiratory depression, which can to! Institute a monitoring plan anticholinergic drugs include some antihistamines, tricyclic antidepressants, medications to control overactive,. Patients requiring therapy with a drug that prolongs QT should be avoided in taking. Cyp3A4 metabolism in clinical trials CNS effects ( e.g., increased sedation or respiratory depression, can. Product when it is important to tell your doctor about all other medications you use, including respiratory,... Cardiovascular effects, including respiratory depression and AUC of CYP3A4 substrates doxepin interactions with wellbutrin clinical.. Cns and cardiovascular effects, while increasing TCA plasma concentration and adverse effects your inbox commercial.... That cause fewer side effects concomitant administration can increase the risk of CNS depressants can result additive. Is for End User 's use only and may not be taken for two weeks and! Insulin regular human by pharmacodynamic synergism would limit the usefulness of doxepin affecting! Some antihistamines, tricyclic antidepressants, medications to control overactive bladder, and fatal respiratory depression and. That cause fewer side effects not be taken for two weeks before and after treatment this!

Cuanto Vive Un Gato Naranja, Providence College Merit Scholarships College Confidential, Tcl 10 Pro Charging Port Replacement, Articles D