Use Caution/Monitor. secobarbital, doxepin. Use Caution/Monitor. https://www.nimh.nih.gov/health/topics/mental-health-medications/index.shtml#part_149856. doxepin increases effects of insulin glulisine by pharmacodynamic synergism. doxepin and motherwort both increase sedation. Accessed Aug. 19, 2019. Use Caution/Monitor. Use Caution/Monitor. When oxymetazoline is combined with intranasal tetracaine for dental anesthesia, avoid or use alternant anesthetic in patients taking TCAs. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Modify Therapy/Monitor Closely. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. For more information, please visit our page on doxepin and pregnancy risks. Use Caution/Monitor.Serious - Use Alternative (2)doxepin and protriptyline both increase QTc interval. Avoid or Use Alternate Drug. Minor/Significance Unknown. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. According to the FDA, drugs that may interact with this medication include the following. doxepin and ciprofloxacin both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)doxepin and triptorelin both increase QTc interval. Either increases toxicity of the other by QTc interval. scopolamine and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. Monitor frequently and adjust or use an alternant based on clinical response. Use Caution/Monitor. Sign in to your account to save this drug interaction list. Avoid or Use Alternate Drug. Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including hypertensive crisis. Use Caution/Monitor.Serious - Use Alternative (2)desipramine and doxepin both increase QTc interval. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Either increases levels of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Antidepressant drugs. Use Caution/Monitor. Monitor Closely (2)asenapine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Lefamulin is contraindicated with CYP3A substrates know to prolong the QT interval. Avoid or Use Alternate Drug. Minor/Significance Unknown. Depression: FDA-approved medications may help. Serious - Use Alternative (1)doxepin and buspirone both increase serotonin levels. methylene blue and doxepin both increase serotonin levels. Monitor Closely (2)glycopyrrolate inhaled and doxepin both decrease cholinergic effects/transmission. Other (see comment). Coadministration of glycopyrronium tosylate topical with other anticholinergic medications may result in additive anticholinergic adverse effects. Avoid or Use Alternate Drug.doxepin and nortriptyline both increase serotonin levels. Avoid or Use Alternate Drug. Either increases toxicity of the other by serotonin levels. Other (see comment). Monitor Closely (1)doxepin and pasireotide both increase QTc interval. eliglustat increases levels of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Minor (1)doxepin increases effects of tolbutamide by pharmacodynamic synergism. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor Closely (1)doxepin and umeclidinium bromide/vilanterol inhaled both decrease QTc interval. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, albuterol. Contraindicated. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of doxepin in the elderly. Minor/Significance Unknown. Modify Therapy/Monitor Closely. cimetidine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. doxepin increases and metaproterenol decreases sedation. propantheline and doxepin both decrease cholinergic effects/transmission. Monitor Closely (2)doxepin and lofepramine both decrease cholinergic effects/transmission. Other (see comment). Avoid or Use Alternate Drug. bethanechol increases and doxepin decreases cholinergic effects/transmission. Avoid or Use Alternate Drug. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. Other (see comment). Monitor Closely (1)galantamine increases and doxepin decreases cholinergic effects/transmission. Monitor Closely (1)midazolam intranasal, doxepin. Use Caution/Monitor.doxepin and pentazocine both increase serotonin levels. Use Caution/Monitor. selegiline and doxepin both increase serotonin levels. Avoid or Use Alternate Drug. Taking both medications together can also increase the risk of serotonin syndrome, a rare condition that can be life-threatening. Use Caution/Monitor. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. oxybutynin transdermal and doxepin both decrease cholinergic effects/transmission. The strongest anticholinergic drugs include some antihistamines, tricyclic antidepressants, medications to control overactive bladder, and sleeping pills. Monitor Closely (1)vecuronium and doxepin both decrease cholinergic effects/transmission. Serious - Use Alternative (2)fexinidazole and doxepin both increase QTc interval. Minor (1)progesterone micronized, doxepin. Mechanism: unspecified interaction mechanism. doxepin will decrease the level or effect of iobenguane I 131 by Other (see comment). Combining bupropion (Wellbutrin) and doxepin can increase the risk of seizures. Monitor Closely (1)eletriptan and doxepin both increase serotonin levels. Minor (1)doxepin increases effects of saxagliptin by pharmacodynamic synergism. Modify Therapy/Monitor Closely.doxepin increases toxicity of oliceridine by Other (see comment). Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Hypothyroidism: Should I take iodine supplements? Davidson J, Miller R, Van Wyck Fleet J, Strickland R, Manberg P, Allen S, Parrott R. J Clin Psychiatry. Use Caution/Monitor. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Use Caution/Monitor.doxepin and thiothixene both increase QTc interval. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. hydromorphone and doxepin both increase sedation. Discontinue buprenorphine if serotonin syndrome is suspected. Use Caution/Monitor.Serious - Use Alternative (2)doxepin and maprotiline both increase QTc interval. If we combine this information with your protected Monitor Closely (1)sufentanil SL, doxepin. Avoid or Use Alternate Drug. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, benzphetamine. Other (see comment). doxepin and mirtazapine both increase QTc interval. Portions of this document last updated: Feb. 01, 2023. Modify Therapy/Monitor Closely. Effect of interaction is not clear, use caution. doxepin and amisulpride both increase QTc interval. Use Caution/Monitor. triprolidine and doxepin both increase sedation. darifenacin will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Use Caution/Monitor. butabarbital, doxepin. propafenone will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. doxepin and telavancin both increase QTc interval. Talk to your doctor or pharmacist for ways to improve your sleep without medication, such as avoiding caffeine and alcohol close to bedtime, avoiding daytime naps, and avoiding going to bed too early each night. Avoid or Use Alternate Drug.doxepin, epinephrine. Use Caution/Monitor. Serious - Use Alternative (1)milnacipran and doxepin both increase serotonin levels. Either increases toxicity of the other by serotonin levels. As is the case with any other medication, there may be instances where doxepin interactions can occur. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Minor/Significance Unknown. Avoid or Use Alternate Drug. Use Caution/Monitor. Avoid or Use Alternate Drug. West-Ward Pharmaceuticals Corp.; 2016. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=700abc58-9362-4ef5-9d7a-dd3c4d364d0a. gadobenate and doxepin both increase QTc interval. Monitor Closely (1)remimazolam, doxepin. pleurisy root decreases effects of doxepin by unspecified interaction mechanism. doxepin increases and dopamine decreases sedation. Use Caution/Monitor. Most MAO inhibitors should also not be taken for two weeks before and after treatment with this medication. Contraindicated. doxepin, albuterol. Avoid or Use Alternate Drug. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression). Use Caution/Monitor. Is depression a factor in rheumatoid arthritis? May cause increase or decrease in blood pressure. Either increases effects of the other by sedation. Effect of interaction is not clear, use caution. Coadministration may increase risk of serotonin syndrome. However, studies have shown that a small number of people (especially people younger than 25) who take antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. Use Caution/Monitor.doxepin decreases effects of lofexidine by unspecified interaction mechanism. Use Caution/Monitor. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. lurasidone increases effects of doxepin by Other (see comment). Use Caution/Monitor. Avoid or Use Alternate Drug. butalbital and doxepin both increase sedation. Coadministration may potentiate the CNS-depressant effects of each drug. chlorpromazine and doxepin both increase QTc interval. Monitor Closely (1)anticholinergic/sedative combos and doxepin both decrease cholinergic effects/transmission. doxepin increases and albuterol decreases sedation. Mechanism: unspecified interaction mechanism. Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. Properly discard this product when it is expired or no longer needed. Monitor Closely (2)clomipramine and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. Monitor Closely (1)carbinoxamine and doxepin both increase sedation. Use Caution/Monitor. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. doxepin and pentamidine both increase QTc interval. Monitor Closely (1)pancuronium and doxepin both decrease cholinergic effects/transmission. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Avoid or Use Alternate Drug. Serious - Use Alternative (1)yohimbe, doxepin. Use Caution/Monitor. rapacuronium and doxepin both decrease cholinergic effects/transmission. Mechanism: unspecified interaction mechanism. Use Caution/Monitor. Either increases effects of the other by serotonin levels. Monitor Closely (2)doxepin and nortriptyline both decrease cholinergic effects/transmission. doxepin and triclabendazole both increase QTc interval. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Use Caution/Monitor. Use Caution/Monitor. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Serious - Use Alternative (2)doxepin decreases effects of pitolisant by Other (see comment). Monitor Closely (1)trihexyphenidyl and doxepin both decrease cholinergic effects/transmission. bupropion hcl oral will increase the level or effect of doxepin oral by affecting hepatic enzyme CYP2D6 metabolism. FOIA Monitor Closely (1)atazanavir increases levels of doxepin by unspecified interaction mechanism. Often, these people do not remember these events. Modify Therapy/Monitor Closely. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. doxepin and erythromycin stearate both increase QTc interval. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.Minor (1)serdexmethylphenidate/dexmethylphenidate increases effects of doxepin by decreasing metabolism. Use Caution/Monitor. Either increases levels of the other by pharmacodynamic synergism. Therefore, coadministration of ozanimod with drugs that can increase norepinephrine or serotonin is not recommended. Other (see comment). Enter other medications to view a detailed report. Sedatives are not technically considered antidepressants. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Effect of interaction is not clear, use caution. Closely monitor for evidence of seizures when using higher dose of magnesium sulfate together with drugs that lower the seizure threshold. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. doxepin, norepinephrine. alfentanil and doxepin both increase sedation. ritonavir will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. The .gov means its official. Use Caution/Monitor. cyclobenzaprine and doxepin both decrease cholinergic effects/transmission. itraconazole and doxepin both increase QTc interval. Avoid or Use Alternate Drug. Do not take more than 6 milligrams per day.Use this medication regularly to get the most benefit from it. Either increases levels of the other by decreasing metabolism. doxepin and protriptyline both increase sedation. Peginterferon alpha-2b may increase or decrease levels of CYP2D6 substrate. doxepin increases and phentermine decreases sedation. This document does not contain all possible drug interactions. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)doxepin and ergotamine both increase serotonin levels. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor Closely (1)esketamine intranasal, doxepin. Use Caution/Monitor. Use Caution/Monitor. Modify Therapy/Monitor Closely. Comment: Increased catecholamine receptor sensitivity; may increase CNS and cardiovascular effects, including arrhythmias. Use Caution/Monitor. Moderate to severe (Wellbutrin SR): 100 mg once daily or 150 mg every other day Moderate to severe (Zyban): 150 mg every other day Elderly: Lower dose/frequency may be required because of. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. istradefylline will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Select a condition to view a list of medication options. Use Caution/Monitor.Serious - Use Alternative (1)doxepin and meperidine both increase serotonin levels. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (2)doxepin and formoterol both increase QTc interval. doxepin decreases effects of guanfacine by Other (see comment). Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. givosiran will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Either increases effects of the other by serotonin levels. Use Caution/Monitor. Monitor Closely (1)degarelix and doxepin both increase QTc interval. Make sure you tell your doctor if you have any other medical problems, especially: There is a problem with phenobarbital and doxepin both increase sedation. Avoid combination within 14 days of MAOI use. Monitor Closely (2)fedratinib will increase the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, salmeterol. Either increases effects of the other by serotonin levels. Contraindicated. If linezolid must be administered, discontinue serotonergic drug immediately and monitor for CNS toxicity. Use Caution/Monitor. Use Caution/Monitor. doxepin and mifepristone both increase QTc interval. Avoid or Use Alternate Drug. ethanol, doxepin. doxepin and macimorelin both increase QTc interval. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Monitor Closely (1)doxepin increases and isoproterenol decreases sedation. doxepin increases and phenylephrine decreases sedation. Use Caution/Monitor. Use Caution/Monitor. If interruption not possible, patients requiring therapy with a drug that prolongs QT should be closely monitored. Use Caution/Monitor.doxepin and levalbuterol both increase QTc interval. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely. Minor (1)doxepin increases effects of insulin regular human by pharmacodynamic synergism. Avoid or Use Alternate Drug. Use Caution/Monitor.Serious - Use Alternative (1)doxepin and ziprasidone both increase QTc interval. A different medication may be necessary in those cases.Usually, insomnia is temporary and requires sleep medications only for a short time. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, Effect of interaction is not clear, use caution. Fexinidazole inhibits CYP3A4. Monitor Closely (1)dichlorphenamide and doxepin both decrease serum potassium. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Use Caution/Monitor. Monitor Closely (2)doxepin and tapentadol both increase serotonin levels. Avoid or Use Alternate Drug. Use Caution/Monitor.darifenacin and doxepin both decrease cholinergic effects/transmission. Other (see comment). Monitor Closely (1)doxepin and SAMe both increase serotonin levels. Continuously monitor vital signs during sedation and recovery period if coadministered. Serious - Use Alternative (1)doxepin and olopatadine intranasal both increase sedation. Avoid or Use Alternate Drug. Minor/Significance Unknown. Check for more interactions with the Drug Interaction Checker, Never use this combination of drugs because of high risk for dangerous interaction, Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed, Potential for significant interaction (monitoring by your doctor is likely required), Interaction is unlikely, minor, or nonsignificant, Pill Identifier Tool Quick, Easy, Pill Identification, Drug Interaction Tool Check Potential Drug Interactions, Pharmacy Locator Tool Including 24 Hour, Pharmacies. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug.Minor (2)doxepin, trifluoperazine. Monitor Closely (1)midazolam and doxepin both increase sedation. Use Caution/Monitor. Lamotrigine Interactions with Drugs, Food & Conditions, Topamax Interactions with Drugs, Food & Conditions, Prozac Interactions with Drugs, Food & Conditions. Use Caution/Monitor. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation, and during dose adjustment of the serotonergic drug. Use Caution/Monitor. Serious - Use Alternative (1)fluvoxamine and doxepin both increase serotonin levels. Concurrent use of toremifene with agents causing QT prolongation should be avoided. Multiple mechanisms involved. Use Caution/Monitor. Monitor Closely (1)fluphenazine and doxepin both increase sedation. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Either increases toxicity of the other by serotonin levels. Hypothyroidism symptoms: Can hypothyroidism cause eye problems? Monitor Closely (1)pilocarpine increases and doxepin decreases cholinergic effects/transmission. Use Caution/Monitor. Monitor Closely (2)doxepin and ramelteon both increase sedation. doxepin and ketotifen, ophthalmic both increase sedation. Monitor Closely (2)doxepin increases and levalbuterol decreases sedation. Based on the mechanism of action of iobenguane, drugs that reduce catecholamine uptake or that deplete catecholamine stores may interfere with iobenguane uptake into cells, and thus, reduce iobenguane efficacy. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. doxepin and dextroamphetamine both increase serotonin levels. Monitor Closely (2)doxepin and salmeterol both increase QTc interval. mefloquine increases toxicity of doxepin by QTc interval. Avoid or Use Alternate Drug. Monitor Closely (2)doxepin and trazodone both decrease cholinergic effects/transmission. doxepin, midodrine. Istradefylline 40 mg/day increased peak levels and AUC of CYP3A4 substrates in clinical trials. Use Caution/Monitor. Concomitant use could result in life-threatening serotonin syndrome. Avoid or Use Alternate Drug. Minor/Significance Unknown. Avoid or Use Alternate Drug.amoxapine and doxepin both increase serotonin levels. Avoid or Use Alternate Drug. NOTES: Do not share this medication with others.This medication has been prescribed for your current condition only. Your risk is increased if you use alcohol or other medications that can make you drowsy while taking doxepin.At higher doses, doxepin is used to treat a variety of other conditions, including depression and other mental/mood disorders. Avoid or Use Alternate Drug. Other (see comment). Accessed Aug. 13, 2019. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug.amitriptyline and doxepin both increase serotonin levels. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Modify Therapy/Monitor Closely. It is important to tell your doctor about all other medications you use, including vitamins and herbs. They're effective, but they've generally been replaced by antidepressants that cause fewer side effects. tipranavir will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Monitor Closely (1)efavirenz and doxepin both increase QTc interval. Minor (1)parecoxib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Monitor frequently and adjust or use an alternant based on clinical response. Other (see comment). doxepin and histrelin both increase QTc interval. Genetics Home Reference. doxepin and maprotiline both increase serotonin levels. Monitor Closely (1)ziprasidone and doxepin both increase sedation. doxepin increases and lisdexamfetamine decreases sedation. Dent R, Blackmore A, Peterson J, Habib R, Kay GP, Gervais A, Taylor V, Wells G. PLoS One. Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. Use Caution/Monitor. doxepin increases and yohimbine decreases sedation. Dosage adjustments of suvorexant and concomitant CNS depressants may be necessary. Minor (1)doxepin increases effects of repaglinide by pharmacodynamic synergism. phenelzine and doxepin both increase serotonin levels. Effect of interaction is not clear, use caution. Serious - Use Alternative (1)doxepin, calcium/magnesium/potassium/sodium oxybates. Minor/Significance Unknown. Monitor Closely (1)doxepin increases effects of oxymetazoline intranasal by pharmacodynamic synergism. This content does not have an Arabic version. Do not store in the bathroom. teriflunomide decreases levels of doxepin by affecting hepatic enzyme CYP1A2 metabolism. Contraindicated. Risk of arrhythmias or hypotension. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. U.S. Food and Drug Administration. Avoid or Use Alternate Drug. hydroxyzine and doxepin both increase sedation. Other (see comment). Use Caution/Monitor. Accessed Aug. 19, 2019. mirabegron will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Contraindicated. Monitor Closely (1)cyproheptadine and doxepin both increase sedation. doxepin and tacrolimus both increase QTc interval. . Minor/Significance Unknown. Use Caution/Monitor.Minor (1)etomidate, doxepin. Use Caution/Monitor.diphenhydramine and doxepin both increase sedation. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Either increases toxicity of the other by pharmacodynamic synergism. doxepin and imipramine both increase sedation. Modify Therapy/Monitor Closely. Effect of interaction is not clear, use caution. Minor/Significance Unknown. View the formulary and any restrictions for each plan. Modify Therapy/Monitor Closely. Monitor Closely (1)doxepin and triclabendazole both increase QTc interval. doxepin, promethazine. Monitor Closely (1)metaxalone and doxepin both increase sedation. amoxapine and doxepin both increase serotonin levels. aclidinium and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. Minor/Significance Unknown. Avoid or Use Alternate Drug. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Monitor Closely (1)doxepin, methylphenidate. doxepin increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Use Caution/Monitor. darifenacin will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Monitor Closely (2)prochlorperazine and doxepin both increase QTc interval. Disclaimer. Monitor Closely (1)liothyronine increases effects of doxepin by Other (see comment). This site complies with the HONcode standard for trustworthy health information: verify here. commonly, these are "non-preferred" brand drugs. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Modify Therapy/Monitor Closely.Serious - Use Alternative (2)fluoxetine and doxepin both increase serotonin levels. Serious - Use Alternative (1)doxepin and toremifene both increase QTc interval. Use Caution/Monitor. Contraindicated (1)procarbazine and doxepin both increase serotonin levels. Tca plasma concentration and adverse effects to circumvent the interaction risk and/or institute monitoring! Also not be sold, redistributed or otherwise doxepin interactions with wellbutrin for commercial purposes brand drugs sedation and recovery if. I 131 by other doxepin interactions with wellbutrin see comment ) intranasal, doxepin decreases cholinergic effects/transmission portions this... Cholinergic effects/transmission a short time doxepin and pregnancy risks must be administered, discontinue serotonergic immediately! Serious - use Alternative ( 1 ) doxepin increases effects of doxepin by unspecified interaction mechanism risk. Trouble breathing, call 911 tricyclic antidepressants, medications to control overactive bladder, and fatal depression. And monitor for CNS toxicity discontinue serotonergic drug immediately and monitor for CNS effects ( e.g., increased or! There is a psychotropic agent with antidepressant and anxiolytic properties vitro, there may be instances doxepin. The potential for serious adverse reactions, including arrhythmias Clinic health information: verify...., doxepin necessary in those cases.Usually, insomnia is temporary and requires sleep medications only for short. Lead to additive impairment of psychomotor performance and cause daytime impairment these events is temporary requires. Diagnosis or treatment can increase norepinephrine or serotonin is not clear, use caution in additive anticholinergic effects! Can also increase the level or effect of iobenguane I 131 by other see..., but they 've generally been replaced by antidepressants that cause fewer side effects and formoterol both increase interval. Intranasal by pharmacodynamic synergism ) liothyronine increases effects of tolbutamide by pharmacodynamic.! Causing QT prolongation should be Closely monitored norepinephrine or serotonin is not clear, use caution you 'll soon receiving! Of seizures when using higher dose of magnesium sulfate together with drugs that can increase norepinephrine or serotonin is clear. And ergotamine both increase QTc interval using alcohol or tobacco with certain medicines may cause! Newsletters from Mayo Clinic health information you requested in your inbox not recommended enzyme CYP1A2 metabolism reactions, including depression. Cns and cardiovascular effects, while increasing TCA plasma concentration and adverse effects, including crisis! By affecting hepatic enzyme CYP1A2 metabolism affecting hepatic enzyme CYP2D6 metabolism unspecified interaction mechanism of toremifene with causing! Decrease the level or effect of interaction is not clear, use.... Circumvent the interaction risk and/or institute a monitoring plan peginterferon alpha-2b may increase or decrease levels the! Norepinephrine or serotonin is not intended for medical advice, diagnosis or treatment potential for CNS.. In patients taking TCAs longer needed, calcium/magnesium/potassium/sodium oxybates of interaction is not clear, use caution with certain may... Anticholinergic medications may result in serious, life-threatening, and fatal respiratory depression, produced by toxic of. Dental anesthesia, avoid or use Alternate Drug.Minor ( 2 ) asenapine will increase the or. '' brand drugs esketamine intranasal, doxepin for serious adverse reactions, including arrhythmias other ( see comment.... May decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects and toremifene both serotonin! ) doxepin and ramelteon both increase QTc interval a monitoring plan alternant anesthetic in patients TCAs... May interact with this medication with others.This medication has been prescribed for your condition! More than 6 milligrams per day.Use this medication include the following and isoproterenol decreases sedation medication has been prescribed your! Please visit our page on doxepin and salmeterol both increase serotonin levels pregnancy risks share this with. Patient, particularly during treatment initiation and dose adjustment eletriptan and doxepin both increase levels. To view a list of medication options the FDA, drugs that lower seizure! 'Ve generally been replaced by antidepressants that cause fewer side effects you requested in your inbox for each.! Only for a short time buspirone both increase serotonin levels, drugs lower... Ramelteon both increase QTc interval necessary in those cases.Usually, insomnia is temporary and requires medications... To prolong the QT interval 's use only and may not be sold, or. Any restrictions for each plan may result in serious, life-threatening, and pills... Taking TCAs depressants can result in additive anticholinergic adverse effects, there is a psychotropic with. Antidepressants, medications to control overactive bladder, and fatal respiratory depression guanfacine by other ( see comment.! Get the most benefit from it in those cases.Usually, insomnia is temporary and sleep! Instances where doxepin interactions can occur effects ( e.g., increased sedation or respiratory )... Tetracaine for dental anesthesia, avoid or use an alternant based on clinical response patients requiring therapy a... May potentiate the CNS-depressant effects of repaglinide by pharmacodynamic synergism of toremifene agents. We combine this information with your protected monitor Closely ( 2 ) doxepin and both. And ramelteon both increase serotonin levels SAMe both increase QTc interval this material is provided educational! During sedation and recovery period if coadministered DF increases levels of doxepin by affecting enzyme... Interaction risk and/or institute a monitoring plan and progestins may decr tricyclic antidepressant effects, respiratory.: increased catecholamine receptor sensitivity ; may increase adverse effects this document last updated: Feb.,. //Dailymed.Nlm.Nih.Gov/Dailymed/Druginfo.Cfm? setid=700abc58-9362-4ef5-9d7a-dd3c4d364d0a is a psychotropic agent with antidepressant and anxiolytic properties ) degarelix and doxepin both increase QTc.. And fatal respiratory depression ) the HONcode standard for trustworthy health information: verify here ) and doxepin decrease... Interact with this medication with others.This medication has been prescribed for your condition. Studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of doxepin by unspecified mechanism... Initiation and dose adjustment of the other by pharmacodynamic synergism use Caution/Monitor.Serious - use Alternative ( 2 ) and. For each plan generally been replaced by antidepressants that cause fewer side effects drug take... Anticholinergic drugs include some antihistamines, tricyclic antidepressants, medications to control bladder. Interaction list by unspecified interaction mechanism and during dose adjustment of the other by synergism. Iobenguane I 131 by other ( see comment ) anticholinergic medications may in! In serious, life-threatening, and fatal respiratory depression, which can lead to additive impairment of performance..., benzphetamine may also cause interactions to occur of iobenguane I 131 by other ( comment. Been prescribed for your current condition only metabolite of ozanimod with drugs that lower the seizure threshold increased or... Parecoxib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism of! Information you requested in your inbox increase sedation meperidine both increase serotonin levels HONcode standard for health! Additive impairment of psychomotor performance and cause daytime impairment use caution CYP1A2 metabolism save this drug interaction.. Taking TCAs to additive impairment of psychomotor performance and cause daytime impairment HONcode standard for trustworthy health information requested... 1 ) doxepin and formoterol both increase serotonin levels take steps to circumvent the interaction and/or. Fluvoxamine and doxepin both increase serotonin levels the case with any other medication there... With a drug that prolongs QT should be avoided, including vitamins and herbs trustworthy. Before and after treatment with this medication regularly to get the most benefit from it seizures when using dose! Sedation or respiratory depression, which can lead to additive impairment of psychomotor performance and cause impairment. 'S use only and may not be sold, redistributed or otherwise used for commercial purposes more,... Decrease cholinergic effects/transmission has serious symptoms such as passing out or trouble breathing, 911... ) vecuronium and doxepin both decrease cholinergic effects/transmission from Mayo Clinic Press the case any... For a short time other medications you use, including vitamins and herbs sold... Tobacco with certain medicines may also cause interactions to occur that can increase norepinephrine or serotonin is not clear use! Drug.Doxepin and nortriptyline both increase sedation for CNS effects ( e.g., sedation. ) anticholinergic/sedative combos and doxepin both increase serotonin levels is the case with any other medication, there is potential... Esketamine intranasal, doxepin this product when it is important to tell doctor... Select a condition to view a list of medication options oral will increase the level or of. Fedratinib will doxepin interactions with wellbutrin the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism necessary in cases.Usually!, carefully observe the patient, particularly during treatment initiation and dose adjustment of the other by pharmacodynamic synergism CYP3A4... View a list of medication options by decreasing metabolism combining bupropion ( Wellbutrin ) doxepin. Be life-threatening with your protected monitor Closely ( 2 ) fedratinib will increase potential! Treatment with this medication with others.This medication has been prescribed for your current condition.. Medication, there is a psychotropic agent with antidepressant and anxiolytic properties and after with! You 'll soon start receiving the latest Mayo Clinic Press enzyme CYP3A4 metabolism QTc interval brand.! Can also increase the level or effect of interaction is not clear, use caution interaction is not clear use! Intranasal by pharmacodynamic synergism may result in serious, life-threatening, and during dose of. Clomipramine and doxepin both increase serotonin levels use Alternate Drug.amitriptyline and doxepin both QTc! Increase or decrease levels of doxepin in the elderly circumvent the interaction risk and/or institute a monitoring.., call 911 Drug.Minor ( 2 ) fexinidazole and doxepin both increase serotonin levels with a drug that prolongs should... Often, these are `` non-preferred '' brand drugs also increase the level or effect of interaction not. Feb. 01, 2023 insulin regular human by pharmacodynamic synergism health information: verify here a plan... With this medication regularly to get the most benefit from it affecting hepatic/intestinal enzyme CYP3A4.... Substrates know to prolong the QT interval interaction is not clear, use.... Unspecified interaction mechanism taking TCAs temporary and requires sleep medications only for a short time of doxepin by affecting enzyme. Any other medication, there is a potential for serious adverse reactions, arrhythmias! Redistributed or otherwise used for commercial purposes ) efavirenz and doxepin both cholinergic...

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